BENADRYL® Caplets provide fast, effective relief from allergies and allergic reactions. Each caplet contains 25 milligrams of diphenhydramine hydrochloride, an antihistamine, to treat sneezing, runny nose, itchy and watery eyes, skin itch, hives, and rashes. Trusted by doctors and moms for more than 60 years, BENADRYL® is safe and effective. BENADRYL® Caplets come in packages of 12, 24, 50, or 100 caplets.